Betulinic acid induces apoptosis by regulating PI3K/Akt signaling and mitochondrial pathways in human cervical cancer cells.

3A , the expression of p27 Kip and p21 Waf1/Cip1 has an increasing trend, and significantly respective went up after 3 and 2 h in duration results ( Fig. 3B ), whereas the level of p21 Waf1/Cip1 phosphorylation reached a plateau and began to decrease after 2 h, indicated a transient phosphorylation pattern in this process.

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