Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Receptor Inhibition.

Gene Ontology enrichment analysis of the cardiotoxic KIs revealed highly significant upregulation of genes involved in transcription and chromatin modification (Figure 5 C and 5 D).

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WP1066 was associated with a nonsignificant trend towards decreased contractile function (fractional shortening 53±2% on Day 7), but co‐administration of erlotinib and WP1066 significantly decreased fractional shortening to 49±2% (Table 2 ; Figure 6 C).

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