Control of protein translation by IP₃R-mediated Ca²⁺ release in Drosophila neuroendocrine cells.

This may be significant in the context of a study by Foskett et al., that reported a role for low level constitutive Ca 2+ leak by IP 3 R in cellular bioenergetics. 16 IP 3 R and AMPK IP 3 R mediated transfer of Ca 2+ from the ER to the mitochondria is now a well established cellular process, studied mainly for its role in apoptosis and autophagy. 17 However, it is also well known that there is a basal requirement for Ca 2+ inside the mitochondria for the production of ATP.

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