Surprisingly, activation of Akt, which leads to a highly significant increase in protein synthesis rates and muscle growth, was not similarly accompanied by a similar strong alteration in gene transcription, particularly at 24 h after Akt activation.
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Comparative Analysis of Muscle Hypertrophy Models Reveals Divergent Gene Transcription Profiles and Points to Translational Regulation of Muscle Growth through Increased mTOR Signaling.
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