Longitudinal Diffusion Tensor Imaging-Based Assessment of Tract Alterations: An Application to Amyotrophic Lateral Sclerosis.

The highly significant correlation between DTI metrics alterations (both FA and AD/RD) with ALS-FRS-R decrease might offer an opportunity to assess disease progression with a lower number of patient visits: an accuracy assessment of the disease progression might either be obtained by a higher number of patient visits (with ALS-FRS-R scores at each visit) or by a less frequent number of visits and a determination of disease progression by ALS-FRS-R in combination with DTI metrics.

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