Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905-1977 in the population-based Tromsø Study 1979-2016.

Tests for interaction with time and birth cohort were highly significant (p values<0.0001), both in models where birth cohorts were included as indicator variables and as one ordinal variable, indicating that the decrease in total cholesterol became significantly steeper the older the birth cohort.

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