Barely Significant
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Smoking and risk of cholangiocarcinoma: a systematic review and meta-analysis.

Oncotarget · 2017 · PMC5725044 · PMID 29246002

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an increasing trendno p-value reported
Despite the significant geographic variation in its incidence, worldwide epidemiological data have shown an increasing trend in the past few years [ 5 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.