Comparison of NMDA and AMPA Channel Expression and Function between Embryonic and Adult Neurons Utilizing Microelectrode Array Systems.

4 , 7 − 9 While neurons derived from embryonic sources are fully differentiated, they are developmentally immature, with transcriptional profiling indicating two-thirds of genes are expressed only postnatally and >95% of the expressed genes showing highly significant changes during postnatal development. 10 , 11 When evaluating the machinery responsible for synaptic transmission, AMPA channel expression is limited at birth, increasing only postnatally. 12 The gene expression for the NMDA channel subunits NR2A and NR2B is not detected until near birth at E21–22,

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