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Rethinking 3R strategies: Digging deeper into AnimalTestInfo promotes transparency in in vivo biomedical research.

PLoS Biol · 2017 · PMC5730105 · PMID 29240762

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an increasing trendno p-value reported
This observation might indicate an increasing trend in research in this area.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.