Lower risk of liver cancer in patients with schizophrenia: a systematic review and meta-analysis of cohort studies.

Schizophrenia and the incidence of liver cancer stratified by gender The pooled results of five cohorts [ 20 , 22 – 25 ], which all excluded patients with cancer events before the diagnosis of schizophrenia, showed that schizophrenia was associated with a significantly higher incidence of liver cancer in male patients (SIR: 0.71, 95% CI: 0.56–0.90, p = 0.005; I 2 = 79%; Figure 3 ), but a nonsignificant trend of a higher incidence of liver cancer in female patients (SIR: 0.83, 95% CI: 0.65–1.05, p = 0.12; I 2 = 63%; Figure 3 ).

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