Integration of GPCR Signaling and Sorting from Very Early Endosomes via Opposing APPL1 Mechanisms.

However, our discovery that endosomal heterogeneity and inter-endosomal communication are essential for coordinating GPCR signaling and sorting will enable the construction of cellular models that integrates GPCR signaling across multiple endosomal compartments, models that could provide insight into complex disease and therapeutic strategies for this highly significant superfamily of receptors.

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