Spotlight on solithromycin in the treatment of community-acquired bacterial pneumonia: design, development, and potential place in therapy.

However, even with these phenotypes included, solithromycin performed well on resistance selection studies; so development of resistance may not be significant and will have to be determined clinically. 35 In vitro activity Solithromycin has demonstrated in vitro efficacy against a wide variety of Gram-positive, Gram-negative, and atypical organisms known to cause pneumonia ( Table 2 ). 10 – 13 , 16 , 17 , 32 , 36 – 43 Although clinical correlation is not complete, solithromycin appears to have a similar spectrum of activity to telithromycin and even some activity against telithromycin-resistant organisms.

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