Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model.

Oncotarget · 2017 · PMC5732764 · PMID 29262598

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Gene set enrichment analysis (GSEA) of genes exhibiting methylation changes from folate depleted recurrent tumors (2,667 loci) revealed a highly significant association with targets of polycomb repressive complex 2 (PRC2) in ES cells, with strong enrichments of regions harboring H3K27me3, and bound by SUZ12 and EED ( Supplementary Table 1 – 2 ).

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