Melanoma cells replicate through chemotherapy by reducing levels of key homologous recombination protein RAD51 and increasing expression of translesion synthesis DNA polymerase ζ.

However, the >2-fold increase in apoptosis between cisplatin-treated DNA pol ζ siRNA-transfected and scrambled siRNA-transfected control wells was highly significant ( P = 0.007 by Student’s t test, n = 4).

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