Genome Wide Mapping of Peptidases in <i>Rhodnius prolixus</i>: Identification of Protease Gene Duplications, Horizontally Transferred Proteases and Analysis of Peptidase A1 Structures, with Considerations on Their Role in the Evolution of Hematophagy in Triatominae.

Arranging species in different taxonomical groups (Hemiptera, Diptera, Hymenoptera, Mixed insect orders, and Non-insects) allowed us to identify 20 peptidase families with significant differentiation among these five sets (Kluskal-Wallis test, p < 0.05; A22, C1, C13, C40, C69, C86, M12B, M17, M19, M38, M79, M87, S1, S10, S24, S28, S33, S54, S60, and S72), including three highly significant ( p < 0.01; C13, M19, and M79; Supplementary Table 7 and Figure 3C ).After comparing R. prolixus protease gene frequencies with the Percentile 90 from the other 18 arthropod genomes, we observed seven families where R. prolixus gene frequencies are higher than in most of other species (greater than Percentile 90): A1, C2, M17, M74, N6, S24, and S29 (Supplementary Figure 2 ).

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