Net Evolutionary Loss of Residue Polarity in Drosophilid Protein Cores Indicates Ongoing Optimization of Amino Acid Composition.

There was a marginally significant ( P < 0.03) age-by-RSA interaction effect for all proteins analyzed together, with the exposed sites showing, as expected, a slightly stronger polarity loss in younger proteins and figure 5 .

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There was a slight trend toward an accelerated rate of net loss of polarity from early to recent ages ( fig. 2 B ), which is particularly evident for substitutions that occurred in the Drosophila melanogaster clade ( fig. 2 A ).

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