p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells.

In agreement with these findings, we observed a highly significant relationship between A3B expression and p53 mutational status in the METABRIC ( P = 7.0 × 10 −8 ) and TCGA ( P = 2.2 × 10 −16 ) breast cancer cohorts (Figure 1A ).

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