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Hepatitis B virus (HBV) X gene mutations and their association with liver disease progression in HBV-infected patients.

Oncotarget · 2017 · PMC5739625 · PMID 29285238

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an increasing trendno p-value reported
Three mutations showed an increasing trend from inactive HBV carriers to cirrhosis and HCC groups.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.