Barely Significant
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Estrogen metabolism in the human lung: impact of tumorigenesis, smoke, sex and race/ethnicity.

Oncotarget · 2017 · PMC5739773 · PMID 29290988

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did not achieve significanceno p-value reported
Furthermore, tobacco smoke exposure elevated 4-OHEs (% total) in both lung tissue and matched urine samples (the urinary results did not achieve significance, possibly due to the small sample size).

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