18 , 20 , 21 Results are mixed, with one study 18 reporting no difference between groups, another 21 reporting results that showed a favorable trend for pharmacist-directed dosing, and the third 20 noted a statistically significant difference between groups.
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Clinical impact of a pharmacist-led inpatient anticoagulation service: a review of the literature.
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Efficacy Several studies failed to show a difference between groups 11 , 14 or saw a significant reduction in supra-/subtherapeutic INR 6 – 8 or a nonsignificant trend toward reduced supra-/ subtherapeutic INR 10 , 13 , 15 when PMAPs were compared to anticoagulation management by a physician.