Such a cellular behavior of 5-Fu was distinguishable from that of curcumin, in which an increasing trend of inhibitory role of curcumin appeared to cover the whole range of the testing concentrations (Fig. 1a , Additional file 1 : Figure S1A).
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Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice.
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