Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?

Front Immunol · 2017 · PMC5742143 · PMID 29312327

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highly significantno p-value reported

In our own studies, Treg ablation in the methylcholanthrene (MCA) carcinogen-induced fibrosarcoma mouse model of carcinogenesis resulted in profound activation of Foxp3 − CD4 + and CD8 + T cells and an overall highly significant reduction in tumor growth rate.

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