Restoration of DAP Kinase Tumor Suppressor Function: A Therapeutic Strategy to Selectively Induce Apoptosis in Cancer Cells Using Immunokinase Fusion Proteins.

Treatment of mice with the maximum tolerable dose of 70 μg resulted in the following positive pre-clinical outcomes: (1) a highly significant overall survival time of greater than 175 days when compared with each control group (administered PBS and non-specific DAPk2-H22(scFv)) with 55 to 60 days mean survival times and (2) the presence of disseminated tumors were evident in the liver, lungs, spleen, and brain of mice in the control group after histological evaluation of prepared tissue sections [ 63 ].

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