The divergent residues in the Ca v 2.2 EF-hand may be significant enough to facilitate interaction of CaM with the pre-IQ-IQ in ways that are unnecessary for Ca v 2.1.
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Molecular moieties masking Ca<sup>2+</sup>-dependent facilitation of voltage-gated Ca<sub>v</sub>2.2 Ca<sup>2+</sup> channels.
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