Cyclic versus Noncyclic Chelating Scaffold for <sup>89</sup>Zr-Labeled ZEGFR:2377 Affibody Bioconjugates Targeting Epidermal Growth Factor Receptor Overexpression.

Corresponding studies with 89 Zr-DFO-ZEGFR:2377 resulted in 17.7 ± 0.3% (A431) and 23.8 ± 0.2% (MDA468) cell-associated radioactivity. Pretreatment of A431 and MDA468 cells with EGFR specific antibody cetuximab led to a highly significant (<0.3% of total activity; P < 1 × 10 –6 ) reduction of binding of 89 Zr-labeled affibody bioconjugates indicating highly specific targeting properties ( Figure 3 A).

also in 132,142 other papers