Histologic Grade Is Predictive of Incidence of Epidermal Growth Factor Receptor Mutations in Metastatic Lung Adenocarcinoma.

The association of grade and the incidence of EGFR mutation remains highly significant in multivariable analysis, with crude OR of 5.0 and adjusted OR of 4.7 (both p = 0.01, Table 2 ).

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The difference in distributions of age at stage IV diagnosis for patients without EGFR mutations when compared to patients with EGFR mutation approaches statistical significance (Median 69 vs. 64, p = 0.07, Table 1 ).

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However, the wait-time for the result of EGFR mutational analysis may be significant especially for those patients who are symptomatic with high tumor burden and require timely initiation of systemic therapy.

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