Barely Significant
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The earlier, the better: the effects of different administration timepoints of sorafenib in suppressing the carcinogenesis of VEGF in rats.

Cancer Chemother Pharmacol · 2018 · PMC5754402 · PMID 29196964

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a decreasing trendno p-value reported
Although no statistical significance existed between the sorafenib groups, the survival times showed a decreasing trend that corresponded with the administration time of sorafenib.

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