Furthermore, a highly significant genotype × birth cohort interaction effect was found on the age of onset of use of alcohol.
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Personality as an intermediate phenotype for genetic dissection of alcohol use disorder.
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Inversely, a borderline significant association between high levels of HA and heterozygosity has been shown in alcohol-dependent patients with anxiety and depression (Koller et al. 2008 ; Lin et al. 2007 ; Wiesbeck et al. 2004 ).