Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in <i>TAF1</i>.

Proc Natl Acad Sci U S A · 2017 · PMC5754783 · PMID 29229810

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did not achieve significanceno p-value reported

Although there was an apparent inverse relationship between repeat length and the effect on luciferase activity, the differences between SVA constructs did not achieve significance with correction for multiple hypothesis testing.

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highly significantno p-value reported

The number of repeats in these cases ranged from 35 to 52 and showed a highly significant inverse correlation with age at disease onset.

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