Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies.

Redox Biol · 2018 · PMC5756055 · PMID 29306792

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Although, this particular aspect is outside the scope of the present review, understanding how modifications of cancer cell bioenergetics and metabolism affect the NADPH/Nox/ROS pathway or phosphorylation of the upstream target in Nox activation could be highly significant in metabolism-based drug therapeutics. 4.

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