1a ), along with a highly significant (30%) decrease in R t and a corresponding simultaneous increase in transepithelial paracellular diffusion (leak) of 14 C–D-mannitol (J m ) by nearly 100% (Fig. 1b ). 250 μM CoCl 2 produced a greater elevation of HIF-1α (Fig. 1a ).
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Cobalt chloride compromises transepithelial barrier properties of CaCo-2 BBe human gastrointestinal epithelial cell layers.
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