S-adenosyl-methionine (SAM) alters the transcriptome and methylome and specifically blocks growth and invasiveness of liver cancer cells.

As shown in Figure 4F, 4G there is a highly significant (Hypergeometric p=0) overlap between DMCs that differentiate cancer cell lines from NorHep and SAM triggered DMCs (∼30% of DMCs between cancer and normal cells were affected by SAM: SAM reduced the differences in methylation in ∼65% of these DMCs) (Figure 4G ).

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