Peptide-based coatings for flexible implantable neural interfaces.

7B ) the cell proliferation rate showed an increasing trend on PI_v treated substrates: in particular the SC growth was increased on PI_v+IKV (P < 0.05 vs.

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Furthermore, the outcomes on PI_v and PI_v+IKV confirmed the results found in the short-term adhesion analysis, resulting in a positive trend for cellular long-term attachment, differentiation and neurite sprouting for both the sequential surface modifications, thus leading to assume that vinyl groups and vinyl-bound IKV contribute to improve surface compliance for PC12 differentiation (Fig. 5C ).

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