Accumulation of histone variant H3.3 with age is associated with profound changes in the histone methylation landscape.

Nucleic Acids Res · 2017 · PMC5766163 · PMID 28934504

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an increasing trendno p-value reported

In the heart, the relative abundance of H3K36me2 demonstrated an increasing trend over the entire time course consistent with a continuous accumulation of H3.3.

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