Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2.

NU7441 enhanced the cytotoxicity of doxorubicin 2-fold at the LD 50 concentration (doxorubicin alone: LD 50 = 12–13 nM; doxorubicin with 1 μM NU7441 LD 50 = 6 nM), and for both cell lines this effect was highly significant (2-way ANOVA p = 0.0008 for TC-71, p < 0.0001 for VH-64 cells).

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