Gene and MicroRNA Perturbations of Cellular Response to Pemetrexed Implicate Biological Networks and Enable Imputation of Response in Lung Adenocarcinoma.

Functional analysis of the differentially expressed mRNAs In evaluating the top differentially expressed mRNAs (n = 250), we found a highly significant enrichment for several functional annotations (Supplemental Fig. 5 ), including acetylation (genes post-translationally modified by the attachment of at least one acetyl group; n = 85 genes; Fold enrichment = 2.2; Bonferroni-adjusted p = 4.2 × 10 −11 ), mitochondrion (the site of tissue respiration

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