A cross-sectional study of 148 patients treated with a median (range) of 62 (6–165) g/m 2 ifosfamide at 8.1 (0.1–25) years and studied 6 (1–47) months after completion of treatment demonstrated highly significant relationships between higher ifosfamide cumulative dose and greater chronic glomerular (evaluated by radioisotope clearance GFR), proximal tubular [(serum phosphate, serum bicarbonate, renal tubular threshold for phosphate (TmP/GFR) and overall nephrotoxicity (total nephrotoxicity score; a composite of measures of glomerular, proximal and distal nephron function) [ 12 ].
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Late renal toxicity of treatment for childhood malignancy: risk factors, long-term outcomes, and surveillance.
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