markedly significantp < 0.001
Comparing the two re-normalized fractional contributions for HeLa-wt and HeLa-APL-R cells, we found that the differences in both, α A and α B , determined for HeLa-wt and HeLa-APL-R cells are markedly significant (p < 0.001), with α B ≫ α A in HeLa-wt and α A ≫ α B in HeLa-APL-R cells, suggesting that APL * -B species seem to be critical for the mechanism of action of plitidepsin, while APL * -A species seems to be more related with cell defense against APL entry into cells.