How is edaravone effective against acute ischemic stroke and amyotrophic lateral sclerosis?

J Clin Biochem Nutr · 2018 · PMC5773834 · PMID 29371752

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a positive trendno p-value reported

Change in %FVC showed a positive trend with edaravone, although the difference was not statistically significant ( p = 0.0942).

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a favorable trendno p-value reported

Post-hoc analysis suggested a favorable trend among patients meeting the following criteria. 1) scores of ≥2 points on all items of ALSFRS-R, 2) %FVC of ≥80% at baseline, 3) definite or probable ALS (El Escorial/revised Airlie House criteria), 4) disease duration of ≤2 years.

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