¹⁸F-FDG-PET/CT and diffusion-weighted MRI for monitoring a BRAF and CDK 4/6 inhibitor combination therapy in a murine model of human melanoma.

ADC showed a strong and highly significant inverse correlation to microvascular density (CD31, ρ = −0.80; p < 0.001) but no significant correlation to proliferation (Ki-67, ρ = −0.42; p = 0.061). ∆TTL and ∆ADC showed strong and significant inverse correlations (ρ = −0.75; p = 0.002).

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MRI DW-MRI detected an increase in ADC under therapy with a trend toward significance (ADC Therapy : from 0.78 ± 0.10 × 10 −3 mm 2 /s to 0.90 ± 0.13 × 10 −3 mm 2 /s; p = 0.026).

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