Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy.

Proc Natl Acad Sci U S A · 2018 · PMC5777035 · PMID 29269392

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highly significantno p-value reported

Comparing primary screen enrichment values for a given sgRNA with GFP-fluorescence changes in individual sgRNA experiments revealed a highly significant correlation, demonstrating the robustness of the screening approach ( Fig. 3 A ).

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