25 Several large studies have demonstrated an increasing trend in opioid use among noncancer patients with opioids becoming one of the most prescribed classes of medication for chronic noncancer pain in the United States. 6 , 15 , 30 Increased opioid use brings potential therapeutic benefit and a higher rate of adverse drug events (ADEs).
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Pharmacoeconomics of genotyping-based treatment decisions in patients with chronic pain.
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