Structural and functional analysis of an OB-fold in human Ctc1 implicated in telomere maintenance and bone marrow syndromes.

Although the effects of these mutations are subtle over the period of nine populations doublings, in the context of bone marrow syndromes, the onset of which may occur over a long period of time, these subtle changes may be highly significant leading to disease.

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Although the temperature changes, and in particular for mutant V871A, are subtle, in the context of a disease the onset of which may occur over a long period of time, the observed subtle changes in T m for these mutants may be significant.

also in 13,097 other papers