Barely Significant
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The effects of black cohosh on the regulation of estrogen receptor (ERα) and progesterone receptor (PR) in breast cancer cells.

Breast Cancer (Dove Med Press) · 2018 · PMC5779278 · PMID 29403307

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highly significantno p-value reported
However, when compared to control, ICI, E 2 + ICI, BC, BC + E 2 , and BC + ICI showed highly significant downregulation of ERα protein expression.

also in 132,142 other papers

exceedingly significantno p-value reported
Treatment with TAM alone showed exceedingly significant upregulation of ERα protein expression.

also in 76 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.