Expression of βV-Tubulin in Secretory Cells of the Fallopian Tube Epithelium Marks Cellular Atypia.

In the cancer context, βV-tubulin expression in secretory cells may be significant because it is secretory cell outgrowths of the FTE that are implicated in the development of serous ovarian carcinoma. 22 , 24 In the FTE of cases with BRCA mutations or serous ovarian neoplasms, βV-tubulin–positive cells often appeared discohesive, with protrusion toward the FT lumen, and some cells had enriched polarized expression toward the lumen.

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