Young and healthy C57BL/6 J mice performing sprint interval training reveal gender- and site-specific changes to the cortical bone.

The results concerning the female hind legs can be summarized as follows: i) only the cortical bone of the tibiae was responsive to the SIT and showed alterations in the Cs.Th., ii) these alterations included a transient and not quite significant decrease after four weeks of SIT, iii) a very significant increase after eight weeks of SIT with iii) changes occurred at both, endosteal and periosteal surfaces with an emphasis on the distal half of the tibiae.

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