BRIP1 loss-of-function mutations confer high risk for familial ovarian cancer, but not familial breast cancer.

While the association of BRIP1 LoF mutations with early-onset OC (AAD < 51 years) was barely significant (OR = 6.01, 95% CI = 1.45–24.82, P = 0.0471), a high OR of 29.91 (95% CI = 14.99–59.66, P < 0.0001) was observed in OC patients with an AAD ≥ 61 years.

also in 875 other papers

The highly significant associations shown in our study suggest that BRIP1 represents a high-risk gene for late-onset OC, further supporting the notion that RRSO should be considered for BRIP1 mutation carriers.

also in 132,142 other papers