highly significantp <0.01
Pairwise contrasts Amygdala–dorsolateral prefrontal connectivity Post hoc analysis of extracted mean z -statistic values revealed that differences in left amygdala–left DLPFC IC ( Figure 1A ) were driven by a highly significant loss of inverse IC in AO-MDD compared to HC (mean z -statistic =+0.06 vs −1.20, respectively; p <0.01) and EO-MDD patients (mean z -statistic =+0.06 vs −0.43, respectively; p <0.01).