an overall trendP ≤ 0.08
The trend ( P = 0.10) for a time effect on IL-1β was not explained by a linear ( P = 0.21) or quadratic effect ( P = 0.90), but rather by an overall trend ( P ≤ 0.08) for an increase at wk 1 in comparison with wk 0, 2, 3, and 4 ( Fig 4 ).