Prior to Peripheral Tolerance, Newly Generated CD4 T Cells Maintain Dangerous Autoimmune Potential: Fas- and Perforin-Independent Autoimmunity Controlled by Programmed Death-1.

PD-1 −/− HSC recipients at the peak of disease (day 45) demonstrated no significant difference in splenic CD4 or CD8 T cell populations although a small trend toward increased expression in PD-1 −/− HSC recipient CD8 T cells was noted (Figure S2 in Supplementary Material).

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